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Several studies have recently shown that the activity of some eukaryotic transposable elements is sensitive to the presence of homologous transgenes, suggesting the involvement of homology-dependent gene-silencing mechanisms in their regulation. Here we provide data indicating that two non-LTR retrotransposons of Drosophila melanogaster are themselves natural triggers of homology-dependent gene silencing. We show that, in the female germline of D. This silencing is probably mediated by sequence identity with endogenous copies of the retrotransposons because it does not occur with a fragment from the divergent R1 elements of Bombyx mori, and, when a fragment of I is used, it occurs only in females containing functional copies of the I element.
This silencing is not accompanied by cosuppression of the endogenous gene homologous to the chimeric transcription unit, which contrasts to some other silencing mechanisms in Drosophila. These observations suggest that in the female germline of D. Please enable it to take advantage of the complete set of features!
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Abstract Several studies have recently shown that the activity of some eukaryotic transposable elements is sensitive to the presence of homologous transgenes, suggesting the involvement of homology-dependent gene-silencing mechanisms in their regulation.
Losada A, et al. Mol Biol Evol. PMID: Sequence divergence within transposable element families in the Drosophila melanogaster genome. Lerat E, et al.
Genome Res. Epub Jul Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. Aravin AA, et al. Curr Biol. Drost HG, et al. Genome Biol Evol. Telomere-specific non-LTR retrotransposons and telomere maintenance in the silkworm, Bombyx mori. Fujiwara H, et al. Chromosome Res. PMID: Review.
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PLoS Genet. Epub Mar Involvement of a short interspersed element in epigenetic transcriptional silencing of the amoebapore gene in Entamoeba histolytica. Anbar M, et al. Eukaryot Cell. RNA interference: the molecular immune system. Bagasra O, Prilliman KR. Bagasra O, et al. J Mol Histol.
See all "Cited by" articles. References Cell. Publication types Research Support, Non-U. Gov't Actions. MeSH terms Animals Actions.
Animals, Genetically Modified Actions. Crosses, Genetic Actions. Female Actions. In Situ Hybridization Actions.
